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Pharmaceutical Manufacturing Editor-in-Chief Agnes Shanley interviews Dr. Brad Gold, director of pharmaceutical development and new technology at Metrics Inc., about his poster presentation Oct. 26 at the American Association of Pharmaceutical Scientists annual conference.

In his presentation, Gold described how a client's promising prodrug tablet – over-encapsulated in gelatin and being used in clinical trials – failed to dissolve properly after stressed stability storage. The client approached Metrics, seeking understanding of the problem as well as solutions.

Metrics Scientist Deanna Williamson discovered an unexpected trend of a previously unidentified molecule of benzophenone while analyzing stability data of a particularly potent drug stored inside an HDPE bottle.

Benzophenone is a compound that is often used in the varnish coating of a bottle's label. And the molecule had traveled on its own -- through the label and the bottle -- before coming to rest on a tablet inside.