ANALYTICAL EQUIPMENT LIST
QUANTITY/TYPE
- 117 HPLC systems
(Agilent 1200, 1260 and Hitachi Elite 7000 Gradient HPLC Systems, Dionex ICS-2500 IC Systems, Waters 2695, Shimadzu LC-2010 CHT, Shimadzu Prominence UFLC, LC20 capable of pressure up to ~10,000 psi, Waters Alliance with 2998 DAD)
Services include GPC, refractive index, UV, fluorescence, ELS, conductivity, amperometry, and diode-array detection - LC/MS Agilent 6530 Accurate Mass Q-TOF, Equipped with Jet Stream Focusing, ESI and APCI for MS and MS/MS Analyses - 15 GC systems (Perkin Elmer Clarus and Agilent 6890 GC’s, and an Agilent 6890 GC with 5975 MSD.)
Services include capillary and packed column, static headspace, purge and trap, direct injection, FID, NPD, TCD, and MS - 7 UV/VIS Spectrophotometers
- Dissolution Baths (USP Apparatus I, II, III, and Intrinsic Dissolution)
23 Manual sampling
6 Automated sampling
OTHER ANALYTICAL EQUIPMENT/SERVICES
- TLC (with photo documentation)
- FTIR, Near-IR
- Titrations (colorimetric and potentiometric)
- pH
- Karl Fischer (volumetric, blending volumetric, coulometric, volumetric)
- Atomic Absorption (AA) – Flame, Graphite Furnace, and Cold Vapor
- Atomic Emission (AE)
- Inductively Coupled Plasma (ICP)
- Viscometer, Polarimeter, Refractometer, Osmometer, Fluorometer
- TOC
- Laser Diffraction Particle Size (Malvern Mastersizer S)
- Dynamic Light Scattering (Malvern Zetasizer Nano ZS)
- TGA-Thermogravimetric Analysis (TA Instruments)
- DSC-Differential Scanning Calorimetry (TA Instruments)
- Modulated DSC (TA Instruments)
- ITC–Isothermal Calorimetry (Microcal)
METRICS, INC. STABILITY PROGRAM
Chambers available (current):
| 5°C | 25°C/40% RH | 30°C/65%RH |
| 40°C<25% RH | Photostability at 30°C, Ambient Humidity (Option 2) | 30°C/75%RH |
| 40°C/75% RH | -20°C | 55°C |
| 30°C/60% RH | -78°C | 60°C |
| 25°C/60% RH |
MICROBIOLOGICAL EQUIPMENT/SERVICES
- Sterility (Equinox Steritest)
- BET (Pyros Kinetix Turbidimetrics Sytem and Gel–Clot)
- Particulate Matter (Light Obscuration (HIAC) and Optical Microscopy)
- Water Testing (Milliflex Pump System)
- Microbial Enumeration Tests and Tests for Specified Microorganisms per Harmonised USP <61> and <62>.
- Antimicrobial Effectiveness
- Antibiotic Assay—(Cylinder Plate Analysis)
- Environmental Monitoring
