Our 'Thoughtful Science' Philosophy
Scientific excellence combined with significant industry experience has propelled Metrics Inc. into becoming one of the most respected pharmaceutical research, formulation, development and manufacturing companies in the United States today.
Our veteran experts continually practice thoughtful science – going beyond merely documenting findings to thoroughly examining and understanding their "whys" and "hows." The results? More exact data for our clients – and new scientific knowledge that both benefits clients and advances the entire pharmaceutical industry.
Our Expertise
Started as a contract analytical laboratory in 1994, Metrics has evolved into a full-service provider of:
- Quality pharmaceutical formulation development,
- First-time-in-man (FTIM) formulations,
- Clinical material manufacturing (CTM) for Phase I, II and III trials,
- Commercial manufacturing and
- Analytical method development and validation services.
Globally, Metrics provides a broad spectrum of contract services to support investigational new drug (IND), new drug (NDA) and abbreviated new drug (ANDA) submissions to regulatory agencies.
Metrics offers particular expertise in FTIM and Phase I, II, and III CTM manufacturing – conducting more than 130 FTIM projects for different chemical entities in the last five years while developing 700-plus batches of CTM at the same time.
Our Specialty Services
- Potent and cytotoxic. Our dedicated and segregated facility provides total engineered containment of all processes through customized hard-wall isolation technologies and achieves containment ~ 30 nanograms per cubic meter.
- Formulation. Our formulation scientists provide timely analyses and recommendations for finished dose formulations on insoluble actives, unstable actives, potent and toxic actives and small molecule delivery. Metrics provides seamless scale up to commercial manufacture in batch sizes ranging from < 1 kg to 400 kg. Our expertise in final formulation included immediate release, sustained release, tablets and capsules, coated tablets, fast dissolve, chewable tablets, capsule filling, over-encapsulation, enteric coating, matrix release and bi-layer tablets.
- Manufacturing. Our large-scale manufacturing facility has a production capability of 1 billion tablets per year with two packaging lines, two granulating rooms and three compressing rooms, including high-speed tablet presses. Our facility is equipped to handle DEA Schedule II through V compounds.
- Analytical. Metrics provides expert analytical method development and validation on a wide range of testing equipment for API and finished dose forms, as well as compendial testing (USP/NF, JP, BP, EP, ACS) of material. We handle all complex and poorly soluble compound types including potent, toxic, light- and temperature-sensitive, and DEA-regulated.
- Stability Storage. Metrics is renowned for developing and validating stability-indicating methods and has state-of-the-art chamber systems that meet ICH and USP guidelines. Metrics can customize storage conditions as needed.
- Microbiology. We offer antibiotic assay and sterility testing, as well as full microbiological support of sterile and non-sterile products. Our scientists routinely perform sterility testing, bacterial endotoxin and particulate matter testing on parenterals. In addition, Metrics frequently works with unique drug products that require non-traditional handling and testing, and provides referee lab testing, water activity testing and autoclave validation support.
